В. Ф. Беженарь [и др.] // Журнал акушерства и женских болезней. 2003. Том LII, вып. С. 35 47



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1098

© D.M. Khegai, 2009


UDC 616-092.9:611-018:616-002.4

Khegay D.M. Molecules of mean mass and the development of paranecrotic changes in organs of rats with experimentally-induced fracture of the low leg bones // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 2 (31). – Р. 140-142.

State Educational Establishment for Higher Professional Training «Saint-Petersburg State Medical Academy named after I.I. Mechnikov of the Federal Agency for Public Health and Social Development of the Russian Federation», Russia, 195067, St.-Petersburg, Piskarevskiy pr., 47, tel.: 543-96-09, fax: 740-15-24, e-mail: vladlif@mechnik.spb.ru

Summary: Lifetime structural changes of rats’ organs tissues and level of middle mass molecules were examined after experimental fracture of shin bones. Correlation between level of middle mass molecules in a spectrum 250 – 270 nanometers and paranecrotic changes was revealed.

Key words: endogenous intoxication, mean mass molecules, paranecrosis.

References:

1. Александров В.Я., Кислюк И.М. Реакция клеток на тепловой шок: физиологический аспект // Цитология. – 1994. - Т. 36. - № 1. – С. 5-60.

2. Габриэлян Н.И., Липатова В.И. Опыт использования показателя средних молекул в крови для диагностики нефрологических заболеваний у детей // Лабораторное .дело. – 1984. - № 3. – С. 138-140.

3. Граменицкий Е.М. Прижизненная окраска клеток и тканей. – Л., 1963. - 192 с.

4. Копытова Т.В. Молекулы средней массы как субстрат эндогенной интоксикации при тяжёлых дерматозах // Успехи современного естествознания. 2006. - № 9. - С. 7-10.

5. Крыжановский Г.Н. Введение в общую патофизиологию. – М., 2000. - 71 с.

6. Медицинские лабораторные технологии. Справочник под ред. А.И. Карпищенко. - Т.2. – СПб, 2002. - 400 с.

7. Мелконян Г.А. Клиническая оценка содержания МСМ при хирургическом лечении больных раком желудка: автореф. дисс. … канд.мед.наук / Мелконян Г.А. – М., 1998. – 19 с.

8. Пальцев М.А., Аничков Н.М. Патологическая анатомия. – М., 2000.- Т. 1. - С. 11-23.

9. Хомуло П.С. Неврогенный атеросклероз и липидоз аорты. – М., 1972. - С. 237-247.

Information about the authors:

Khegai Dmitriy Melisovich – the post-graduate student of department of traumatology, orthopedics with stomatology course of Saint-Petersburg State Medical Academy named after I.I. Mechnikov, work tel.: (8-812) 543-80-54, home tel.: 8 (812) 590-05-64, e-mail: khegai@pisem.net



1187

© E.F. Agletdinov, Bulygin, L.O. Makasheva, G.M. Abdullina, E.K. Alekhin, F.Н. Kamilov, 2009


UDC 577.158:(615.9:547.562.33):616.69-008.8-092.9:599.323.4.082

Agletdinov E.F., Bulygin K.V., Makasheva L.O., Abdullina G.M., Alekhin E.K., Kamilov F.H. Rat ejaculate antioxidant system state in conditions of subchronic intoxication with biphenyls // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. – № 2(31). – Р. 142-145.

Federal State Educational Institution of Higher Professional Learning «Bashkir State Medical University», Russia, 450077, Ufa, Lenin str., 3, tel.: 8 (347) 272-41-73, e-mail: rectorat@anrb.ru

Summary: Polychlorinated biphenyls (PCBs) are widespread persistent environmental pollutants which disturb normal testicular functions in males. The adverse effects of biphenyls on spermatogenesis and sex steroid hormone biosynthesis revealed. The aim of this study was to elucidate the possible reasons of man's reproductive function suppression. He-male rats were treated by industrial mix of «PCBs» in various doses. The experimental data show that the influence of high-doze biphenyls leads to final failure of all protective cellular reactions, including antioxidant system of glutathione. These results prove the important role of infringements the antioxidant status of sperm in the mechanism reproductive toxicity of biphenyls.

Key words: polychlorinated biphenyls, ejaculate, antioxidant system

References:

1. Майстренко В.Н., Клюев Н.А. Эколого-аналитический мониторинг стойких органических загрязнителей. – М.: БИНОМ. Лаборатория знаний, 2004. - 323 с.

2. Окислительный стресс. Прооксиданты и антиоксиданты / Меньщикова Е.Б., Ланкин В.З., Зенков Н.К., Бондарь И.А. [и др.]. – М.: Фирма «Слово», 2006. – 179 с.

3. Agarwal A., Gupta S., Sikka S. The role of free radicals and antioxidants in reproduction // Curr. Opin Obstet Gynecol. – 2006. – Vol. 18. - Р. 325-332.

4. Desai I.D. Vitamin E analysis methods for animal tissues // Methods in Enzymology. – 1984. – Vol. 105. – P. 138–147.

5. Ellman G.L. Tissue sulfhydryl groups // Arch. Biochem. Biophys. - 1959. - Vol. 82. - № 1. - Р. 70-77.

6. Habig W.H., Palst M.J., Jakoby W.B. Glutathione-S-transferase. The first enzymatic step in mercapturic formation // J. Biol. Chem. – 1973. – Vol. 249. - Р. 7130-7139.

7. Halliwell B., Wasil M. & Grootveld M. Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint // FEBS Letter. – 1987. – Vol. 213. – P. 15–17.

8. Omaye S.T., Turnball J.W., Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids // Methods in Enzymology. – 1971. – Vol. 62. - Р. 1-11.

9. Orlowski M., Meister A. Isolation of gamma-glutamyl transpeptidase from hog kidney // J. Biol. Chem. – 1965. – Vol. 240. - Р. 338–347.

10. Rotruck J.K., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase // Science. – 1973. – Vol. 179. - Р. 588-590.

11. Stall G.E., Vegel C. Purification and properties of glutathione reductase of human erythrocytes // Biochim. Biophys. Ada. – 1969. – Vol. 185. - Р. 39-48.

12. Supriyo De, Saroj K. Pramanik, Arthur L. Williams et al. Toxicity of polychlorobiphenyls and its bioremediation // Int. J. of Human Genetics. – 2004. – Vol. 4. - P. 281-290.

Information about the authors:

Agletdinov Agletdinov Edward Feliksovich - Ph.D. (Medicine), senior teacher of chair of biological and bioorganic chemistry, Bashkir State Medical University, tel. mob. 8-917-433-32-20, e-mail: eagletdinov@yandex.ru

Bulygin K.V. - postgraduate student of chair of biological and bioorganic chemistry, Bashkir State Medical University, tel. mob. 8-917-478-70-29.

Makasheva L.O. - postgraduate student of chair of biological and bioorganic chemistry, Bashkir State Medical University, tel. mob. 8-927-321-74-95.

Abdullina G.M. - Ph.D. (Medicine), associate professor of chair of biological and bioorganic chemistry, Bashkir State Medical University, tel. mob. 8-906-371-39-02.

Kamilov F.Kh. - M.D. (Medicine), professor, head of chair of biological and bioorganic chemistry, Bashkir State Medical University, tel. mob.(347) 272-66-07.

Alekhin Ye.K. - M.D. (Medicine), professor, pro-rector for science, Bashkir State Medical University, tel. mob.(347) 273-75-81.





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